Needle-Free Insulin Drug Delivery
نویسنده
چکیده
For most patients with type 1 diabetes, the worst part of the disease is to tolerate needle after needle, both for glucose measurement and to deliver insulin. In the last two decades, concept of insulin therapy by multiple-dose injection has undergone a miraculous change. Needle-free insulin delivery appeared to be a wonderful approach, and its allure rested in being comfortable and safe. In today’s era, insulin delivery by alternative route is a topic of current interest in the design of drug delivery system. Major global pharmaceutical companies are showing encouraging progress in their attempts to develop alternative insulin delivery technologies. Many such drug delivery systems have been developed for oral, buccal and nasal route. This review article discusses, in brief, the novel and emerging technologies that are in pipeline, including insulin inhalers, insulin spray, insulin pill, insulin analogues, insulin complement, islet cell transplant, implantable insulin pumps and guardian continuous glucose monitoring system.
منابع مشابه
An Evolutionary Approachs in Development of Needle Free Injection Technologies
The demand for novel drug delivery technologies is ever increasing though majority of the drugs are administered via oral, inhalation, transdermal and parenteral route. However, there are large numbers of therapies, particularly protein-based, gene-based and vaccine-based that cannot be delivered by this route for example insulin, growth hormones and other similar biologics. This emerging techn...
متن کاملDelivery of insulin by jet injection: recent observations.
Medi-Ject Corporation (now Antares Pharma, Inc.) has been providing delivery devices for the needle-free administration of insulin for over 25 years. This study was one of the final steps in the development and premarket evaluation of Medi-Ject's newest needle-free system, the Medi-Jector Vision. This study was conducted to evaluate the performance of this device in the hands of experienced jet...
متن کاملTransdermal Delivery : a New Source for Biopharma Innovation Interview : Patrick Alexandre , Ceo , Crossject Designing an Ultrasound - Enabled Insulin Patch P 04 P 18 P 22 Transdermal Delivery , Microneedles & Needle - Free Injection
متن کامل
Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery.
The feasibility of preparing microparticles with high insulin loading suitable for needle-free ballistic drug delivery by spray-freeze-drying (SFD) was examined in this study. The aim was to manufacture dense, robust particles with a diameter of around 50 microm, a narrow size distribution and a high content of insulin. Atomization using ultrasound atomizers showed improved handling of small li...
متن کاملPreparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan as a new strategy for bucal drug delivery of insulin
Objective(s): The purpose of this study is about the preparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan (TMPC) which are made P.E.C method, for bucal drug delivery of insulin.Materials and Methods: First of all have to synthesize methylated pyridinyl chitosan and then for (TMPC) L-cysteine should be attached to methylated pyridinyl chitosan by the fo...
متن کامل